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Technical Notes

  • Lifetime Stability of CIMac™ pDNA Analytical Column

    One of the key steps in purification of plasmid DNA vaccines for therapeutic use is the separation of supercoiled (SC) and open circular (OC) conformations of plasmid DNA. In order to monitor product quantity and the separation of conformations throughout the downstream process as well as to verify the separation quality, accurate, reliable and user-friendly analytical methods need to be in place.

  • Chemical Stability of CIMac™ Analytical Columns

    The stability of QA, DEAE and SO3 CIMac™ Analytical Columns was tested according to the CIP (Cleaning In Place) procedures described in the respective Product Specification Sheets (see Table 1). We compared the separation of a mixture of test proteins, the dynamic binding capacity for BSA and the pressure drop after 50 and 100 CIP procedures with the initial characteristics of the columns.

  • Influence Of The Flow Rate On The Separation Efficiency Of CIMac™ SO3 Analytical Column

    CIMac™ SO3 Analytical Column is a strong cation exchanger based on a monolithic support. This material provides many advantages over conventional stationary phases for the separation of biomacromolecules, such as: low back-pressure, flow-unaffected chromatographic properties and a high resolution power due to a convective flow transport within open large-diameter (1.5 μm) channels.

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